Christian Guerrero-Juarez, Postdoctoral Scholar

UC Irvine Chancellor’s ADVANCE Postdoctoral Fellow

NSF-Simons Center for Multiscale Cell Fate Research Fellow

Go to my Google Scholar profile.


I was born and raised in Morelia, Michoacán, México. I received dual B.S./B.A. Degrees in Biology and Biochemistry at California State University, San Bernardino in 2012, and completed my M.S. and Ph.D. Degrees at University of California, Irvine in the laboratory of Dr. Maksim V. Plikus in 2018 where I studied cellular reprogramming during skin regeneration. As a graduate student, I received funding through the MBRS-IMSD and the NSF Graduate Research Fellowship Programs. Significant awards include the 2015 Susan V. Bryant Graduate Fellowship Award, 2017 Howard A. Schneiderman Graduate Fellowship Award, and Premio Michoacano de la Juventud 2018 – Mérito Académico (2018 Michoacán Youth Prize – Academic Merit) – the highest distinction given by the State Government of Michoacán, Mexico to excelling young professionals in their respective fields. I joined the Nie laboratory in July 2018 as a UC Irvine Chancellor’s ADVANCE Postdoctoral Fellow. Currently, I am an NSF-Simons Center for Multiscale Cell Fate Research Fellow and was a finalist in the 2019 Howard Hughes Medical Institute Hanna H. Gray Postdoctoral Fellowship Program competition. My research interests include cell fate choice and cellular reprogramming during injury and disease, and I seek to use a multiscale approach to better understand these processes as they are realized in vivo. Other research interests include wound healing and regeneration of complex tissues beyond skin (i.e. intestine), adipocyte and hair follicle biology, innate immunity, cancer biology, and patterning.


  • 1. Plikus MV, Guerrero-Juarez CF, Cotsarelis G. Methods for scar reduction by converting scar fibroblasts into adipocytes with hair follicle-derived signals. PCT/US2018/012266; WO2018129101A3. (Filed).
  • Publications:

  • 1. Guerrero-Juarez CF, et al. (2019). Single cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nat Commun. 10(1):650.HIGHLIGHTS IN: 1-3) UCI-Led study reveals how blood cells help wounds heal scar-free. (UCI News, UC News; National Science Foundation); 4) Scar-free wound healing? Mathematics is helping make that a reality. (National Science Foundation).
  • 2. Wang Y, Guerrero-Juarez CF, Qiu Y, Du H, Chen W, Figueroa S, Plikus MV, Nie Q. (2019). A multiscale hybrid mathematical model of epidermal-dermal interactions during skin wound healing. Exp Dermatol.
  • 3. Zhang LJ#, Chen SX, Guerrero-Juarez CF, et al. (2019). Age-related loss of innate immune antimicrobial function of dermal fat is mediated by transforming growth factor beta. Immunity. 50:1-16. (#Corresponding author).
  • 4. Guerrero-Juarez CF, Plikus MV. (2018). Emerging non-metabolic functions of skin fat. Nat Rev Endocrinol. Review. 14(3):163-173.
  • 5. Zwick R*, Guerrero-Juarez CF*, Horsley V, Plikus MV. (2018). Anatomical, physiological and functional diversity of adipose tissue. Cell Metabolism. 27(1):68-83. Review. (*Equal contribution).
  • 6. Guerrero-Juarez CF, et al. (2018). Wound regeneration deficit in rats correlates with low morphogenetic potential and distinct transcriptomic profile of epidermis. J Invest Dermatol. 138(6):1409-1419. COMMENT IN: 1) Hair regeneration under stress. (J Invest Dermatol).
  • 7. Hughes MW, Ting-Xin J, Plikus MV, Guerrero-Juarez CF, Chein-Hong L, Maxson C, Widelitz R, Chuong CM. (2018). Msx2 supports epidermal competency during wound-induced hair follicle neogenesis. J Invest Dermatol. 138(9):2041-2050.
  • 8. Wang Q*, Oh JW*, Lee H, Dhar A, Peng T, Ramos R, Guerrero-Juarez CF, et al. (2017). A multi-scale model for hair follicles reveals heterogeneous skin domains driving rapid spatiotemporal hair growth patterning. eLife. 11;6. pii:e22772. (*Equal contribution). (≥16 citations).
  • 9. Guerrero-Juarez CF, Plikus MV. (2017). Gli-fully halting the progression of fibrosis. Cell Stem Cell. Commentary. 20(6):735-736.
  • 10. Plikus MV#, Guerrero-Juarez CF, et al. (2017). Regeneration. Regeneration of fat cells from myofibroblasts during wound healing. Science. 17;355(6326):748-752. (#Corresponding author). COMMENT IN: 1) Fibroblasts become fat to reduce scarring (Science); 2) Repeal and replace: Adipocyte regeneration in wound repair (Cell Stem Cell). HIGHLIGHTS IN: 1) Study reveals natural process for scar-free wound healing. (UCI News); 2) Scar-free healing is almost here. (Popular Mechanics); 3) Hair cells could heal skin sans scars. (Scientific American); 4) How fat helps wounds heal without scars, by study. (The Guardian).
  • 11. Wang X*, Hsi TC*, Guerrero-Juarez CF, et al. (2015). Principles and mechanisms of regeneration in the mouse model for wound-induced hair follicle neogenesis. Regeneration. 2(4):169-181. (*Equal contribution).
  • 12. Chen CC, Wang L, Plikus MV, Jiang TX, Murray PJ, Ramos R, Guerrero-Juarez CF, et al. (2015). Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell. 161(2): 277-90.
  • 13. Zhang LJ, Guerrero-Juarez CF, Hata T, Bapat SP, Ramos R, Plikus MV, Gallo RL. (2015). Innate Immunity. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science. 347(6217):67-71.
  • 14. Plikus MV, Guerrero-Juarez CF, Treffeisen E, Gay DL. (2014). Epigenetic control of skin and hair follicle regeneration after wounding. Exp Dermatol. 23(7). Review.
  • 15. Guerrero-Juarez CF, Ramos R, Oh JW, Hsi TC, Plikus MV. (2014). Light-emitting hair follicles: studying skin regeneration with in vivo imaging. J Invest Dermatol. 134(6):1496-98. Commentary.
  • 16. Sanchez A, Guerrero-Juarez CF, Ramirez J, Newcomb LL. (2014). Nuclear localized Influenza nucleoprotein N-terminal deletion mutant is deficient in functional vRNP formation. Virol J. 11:155.
  • 17. Oh JW, Hsi TC, Guerrero-Juarez CF, Ramos R, Plikus MV. (2013). Organotypic skin culture. J Invest Dermatol. 133(11). Review.
  • 18. Ramos R, Guerrero-Juarez CF, Plikus MV. (2013). Hair follicle signaling networks: a dermal papilla-centric approach. J Invest Dermatol. 133(10):2306-8. Commentary.
  • 19. Whitaker EL, Filippov V, Fillippova M, Guerrero-Juarez CF, Duerksen-Hughes PJ. (2011). Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells. Cytokine. 56(2):272-81.